Drug interactions
Cariprazine + Voriconazole
Severity: Major
Cariprazine and Voriconazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and increases exposure to cariprazine and its active metabolites, which have long half-lives. This raises the risk of extrapyramidal symptoms, akathisia and sedation.
What this interaction means in plain words
Cariprazine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces cariprazine clearance.
What to do
Reduce the cariprazine dose per labeling, typically by about half, and monitor for adverse effects for some time after changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Voriconazole?
MediHelp rates the interaction as major. Cariprazine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole inhibits CYP3A4 and increases exposure to cariprazine and its active metabolites, which have long half-lives. This raises the risk of extrapyramidal symptoms, akathisia and sedation.
How serious is the interaction between Cariprazine and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the cariprazine dose per labeling, typically by about half, and monitor for adverse effects for some time after changes.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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