Drug interactions
Carisoprodol + Propofol
Severity: Moderate
Carisoprodol and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a potent anesthetic and sedative, and carisoprodol adds further central depression. Together they can deepen sedation and increase the likelihood of respiratory depression and hypotension during procedural or anesthetic use.
What this interaction means in plain words
Carisoprodol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, with carisoprodol and propofol both enhancing GABAergic inhibition.
What to do
Inform the anesthesia team of recent carisoprodol use and titrate propofol cautiously to effect. Monitor oxygen saturation, ventilation and blood pressure continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carisoprodol and Propofol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carisoprodol
Other interactions of Propofol
Frequently asked questions
Can I take Carisoprodol with Propofol?
MediHelp rates the interaction as moderate. Carisoprodol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol is a potent anesthetic and sedative, and carisoprodol adds further central depression. Together they can deepen sedation and increase the likelihood of respiratory depression and hypotension during procedural or anesthetic use.
How serious is the interaction between Carisoprodol and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent carisoprodol use and titrate propofol cautiously to effect. Monitor oxygen saturation, ventilation and blood pressure continuously.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
