Drug interactions
Carvedilol + Elagolix
Severity: Minor
Carvedilol and Elagolix: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix inhibits P-glycoprotein and may raise concentrations of carvedilol, a P-gp substrate. The increase is likely modest but may enhance beta-blocker effects.
What this interaction means in plain words
Carvedilol and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Elagolix belongs to Musculoskeletal.
Why it happens
Elagolix inhibits intestinal P-gp efflux of carvedilol.
What to do
Monitor heart rate and blood pressure when starting elagolix, and reduce the carvedilol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Carvedilol with Elagolix?
MediHelp rates the interaction as minor. Carvedilol and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix inhibits P-glycoprotein and may raise concentrations of carvedilol, a P-gp substrate. The increase is likely modest but may enhance beta-blocker effects.
How serious is the interaction between Carvedilol and Elagolix?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting elagolix, and reduce the carvedilol dose if bradycardia or hypotension develops.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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