Drug interactions
Elagolix + Erythromycin
Severity: Major
Elagolix and Erythromycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase elagolix exposure, raising the risk of adverse effects such as bone loss and liver enzyme elevations. Elagolix labeling restricts use with strong OATP1B1 inhibitors, and erythromycin has inhibitory activity on this transporter.
What this interaction means in plain words
Elagolix and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elagolix belongs to Musculoskeletal; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake (and CYP3A) increases elagolix concentrations.
What to do
Avoid the combination where possible; use an alternative antibiotic such as azithromycin or doxycycline as appropriate. If unavoidable, limit duration and monitor for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
- Elagolix + Ketoconazole Major
Frequently asked questions
Can I take Elagolix with Erythromycin?
MediHelp rates the interaction as major. Elagolix and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin may increase elagolix exposure, raising the risk of adverse effects such as bone loss and liver enzyme elevations. Elagolix labeling restricts use with strong OATP1B1 inhibitors, and erythromycin has inhibitory activity on this transporter.
How serious is the interaction between Elagolix and Erythromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; use an alternative antibiotic such as azithromycin or doxycycline as appropriate. If unavoidable, limit duration and monitor for adverse effects.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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