Drug interactions
Carvedilol + Leflunomide
Severity: Minor
Carvedilol and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide, the active metabolite of leflunomide, inhibits CYP2C9, which contributes to carvedilol metabolism. Carvedilol levels may rise modestly, with possible additional bradycardia or hypotension.
What this interaction means in plain words
Carvedilol and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Leflunomide belongs to Musculoskeletal.
Why it happens
Teriflunomide inhibits CYP2C9, slightly reducing carvedilol clearance.
What to do
Monitor heart rate and blood pressure when starting leflunomide. Reduce the carvedilol dose if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Leflunomide?
MediHelp rates the interaction as minor. Carvedilol and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide, the active metabolite of leflunomide, inhibits CYP2C9, which contributes to carvedilol metabolism. Carvedilol levels may rise modestly, with possible additional bradycardia or hypotension.
How serious is the interaction between Carvedilol and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting leflunomide. Reduce the carvedilol dose if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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