Drug interactions
Carvedilol + Nintedanib
Severity: Moderate
Carvedilol and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol inhibits P-glycoprotein and may increase nintedanib exposure, as nintedanib is a P-gp substrate. Higher levels could increase gastrointestinal and hepatic adverse effects.
What this interaction means in plain words
Carvedilol and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Nintedanib belongs to Oncology.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by carvedilol increases nintedanib absorption.
What to do
Monitor for diarrhea, nausea and liver enzyme elevation. Manage adverse effects with supportive care, dose reduction or interruption of nintedanib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Clarithromycin + Nintedanib Moderate
Frequently asked questions
Can I take Carvedilol with Nintedanib?
MediHelp rates the interaction as moderate. Carvedilol and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol inhibits P-glycoprotein and may increase nintedanib exposure, as nintedanib is a P-gp substrate. Higher levels could increase gastrointestinal and hepatic adverse effects.
How serious is the interaction between Carvedilol and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, nausea and liver enzyme elevation. Manage adverse effects with supportive care, dose reduction or interruption of nintedanib.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Albuterol, Amifostine, Amiodarone. The full list is on the Carvedilol page.
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