Drug interactions
Carbamazepine + Nintedanib
Severity: Moderate
Carbamazepine and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may reduce nintedanib exposure and therefore its antifibrotic efficacy. Nintedanib is a P-glycoprotein substrate and a minor CYP3A4 substrate, both of which carbamazepine induces.
What this interaction means in plain words
Carbamazepine and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Nintedanib belongs to Oncology.
Why it happens
Induction of P-glycoprotein and CYP3A4 reduces nintedanib absorption and increases its elimination.
What to do
Prefer an alternative anticonvulsant without enzyme-inducing properties. If coadministration is necessary, monitor for reduced therapeutic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
- Clarithromycin + Nintedanib Moderate
Frequently asked questions
Can I take Carbamazepine with Nintedanib?
MediHelp rates the interaction as moderate. Carbamazepine and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may reduce nintedanib exposure and therefore its antifibrotic efficacy. Nintedanib is a P-glycoprotein substrate and a minor CYP3A4 substrate, both of which carbamazepine induces.
How serious is the interaction between Carbamazepine and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative anticonvulsant without enzyme-inducing properties. If coadministration is necessary, monitor for reduced therapeutic response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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