Drug interactions
Azithromycin + Nintedanib
Severity: Moderate
Azithromycin and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin may inhibit P-glycoprotein and increase nintedanib exposure, potentially worsening gastrointestinal effects and liver enzyme elevations.
What this interaction means in plain words
Azithromycin and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Nintedanib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by azithromycin reduces nintedanib efflux.
What to do
Monitor for diarrhea, nausea and elevated liver enzymes, and interrupt or reduce the nintedanib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
- Clarithromycin + Nintedanib Moderate
Frequently asked questions
Can I take Azithromycin with Nintedanib?
MediHelp rates the interaction as moderate. Azithromycin and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin may inhibit P-glycoprotein and increase nintedanib exposure, potentially worsening gastrointestinal effects and liver enzyme elevations.
How serious is the interaction between Azithromycin and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, nausea and elevated liver enzymes, and interrupt or reduce the nintedanib dose if adverse effects occur.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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