Drug interactions
Clarithromycin + Nintedanib
Severity: Moderate
Clarithromycin and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase nintedanib exposure by inhibiting its efflux, which can worsen gastrointestinal effects such as diarrhea, nausea and vomiting and raise the risk of liver enzyme elevation.
What this interaction means in plain words
Clarithromycin and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Nintedanib belongs to Oncology.
Why it happens
Clarithromycin inhibits P-glycoprotein, a transporter that limits nintedanib absorption and promotes its clearance.
What to do
Monitor closely for adverse effects and liver enzymes; manage with symptomatic treatment, dose reduction or temporary interruption of nintedanib as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Clarithromycin with Nintedanib?
MediHelp rates the interaction as moderate. Clarithromycin and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may increase nintedanib exposure by inhibiting its efflux, which can worsen gastrointestinal effects such as diarrhea, nausea and vomiting and raise the risk of liver enzyme elevation.
How serious is the interaction between Clarithromycin and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse effects and liver enzymes; manage with symptomatic treatment, dose reduction or temporary interruption of nintedanib as needed.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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