Drug interactions
Amiodarone + Nintedanib
Severity: Moderate
Amiodarone and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein and may increase nintedanib exposure. This may worsen gastrointestinal effects, hepatotoxicity and bleeding risk, and both drugs carry hepatic and pulmonary relevance.
What this interaction means in plain words
Amiodarone and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Nintedanib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux of nintedanib by amiodarone.
What to do
Monitor liver enzymes and tolerability closely. Interrupt or reduce nintedanib dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Nintedanib
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
- Clarithromycin + Nintedanib Moderate
Frequently asked questions
Can I take Amiodarone with Nintedanib?
MediHelp rates the interaction as moderate. Amiodarone and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits P-glycoprotein and may increase nintedanib exposure. This may worsen gastrointestinal effects, hepatotoxicity and bleeding risk, and both drugs carry hepatic and pulmonary relevance.
How serious is the interaction between Amiodarone and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and tolerability closely. Interrupt or reduce nintedanib dose if adverse effects develop.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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