Drug interactions
Argatroban + Nintedanib
Severity: Moderate
Argatroban and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nintedanib inhibits VEGF receptor signaling and has been associated with an increased risk of bleeding. In patients on full-dose anticoagulation such as argatroban, bleeding risk may be further increased.
What this interaction means in plain words
Argatroban and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Nintedanib belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: VEGFR inhibition by nintedanib affects vascular integrity and hemostasis while argatroban inhibits thrombin.
What to do
Monitor patients closely for bleeding and check aPTT and hemoglobin; use nintedanib only if the anticipated benefit outweighs the bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
- Clarithromycin + Nintedanib Moderate
Frequently asked questions
Can I take Argatroban with Nintedanib?
MediHelp rates the interaction as moderate. Argatroban and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nintedanib inhibits VEGF receptor signaling and has been associated with an increased risk of bleeding. In patients on full-dose anticoagulation such as argatroban, bleeding risk may be further increased.
How serious is the interaction between Argatroban and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients closely for bleeding and check aPTT and hemoglobin; use nintedanib only if the anticipated benefit outweighs the bleeding risk.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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