Drug interactions
Carvedilol + Nitisinone
Severity: Minor
Carvedilol and Nitisinone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9 in vitro, and CYP2C9 contributes to carvedilol metabolism, mainly for the S(-) enantiomer. Because CYP2D6 is the major pathway, the effect on carvedilol exposure is likely small.
What this interaction means in plain words
Carvedilol and Nitisinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Nitisinone belongs to Miscellaneous.
Why it happens
Nitisinone inhibits CYP2C9, which is a minor pathway of carvedilol metabolism.
What to do
No routine adjustment is needed. Monitor heart rate and blood pressure after nitisinone is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Carvedilol with Nitisinone?
MediHelp rates the interaction as minor. Carvedilol and Nitisinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitisinone inhibits CYP2C9 in vitro, and CYP2C9 contributes to carvedilol metabolism, mainly for the S(-) enantiomer. Because CYP2D6 is the major pathway, the effect on carvedilol exposure is likely small.
How serious is the interaction between Carvedilol and Nitisinone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor heart rate and blood pressure after nitisinone is started.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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