Drug interactions
Fluvastatin + Nitisinone
Severity: Moderate
Fluvastatin and Nitisinone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone weakly inhibits CYP2C9, the main enzyme that clears fluvastatin. Fluvastatin exposure may therefore rise, increasing the chance of dose-related statin adverse effects such as myopathy.
What this interaction means in plain words
Fluvastatin and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Nitisinone belongs to Miscellaneous.
Why it happens
Nitisinone inhibits CYP2C9-mediated metabolism of fluvastatin.
What to do
Monitor for muscle symptoms and consider a lower fluvastatin dose if the combination is needed. Check creatine kinase if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Ganciclovir + Nitisinone Moderate
Frequently asked questions
Can I take Fluvastatin with Nitisinone?
MediHelp rates the interaction as moderate. Fluvastatin and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitisinone weakly inhibits CYP2C9, the main enzyme that clears fluvastatin. Fluvastatin exposure may therefore rise, increasing the chance of dose-related statin adverse effects such as myopathy.
How serious is the interaction between Fluvastatin and Nitisinone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider a lower fluvastatin dose if the combination is needed. Check creatine kinase if symptoms appear.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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