Drug interactions
Diclofenac + Nitisinone
Severity: Moderate
Diclofenac and Nitisinone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9 and may raise exposure to diclofenac, a CYP2C9 substrate. Higher diclofenac levels could increase gastrointestinal, renal and cardiovascular adverse effects.
What this interaction means in plain words
Diclofenac and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Nitisinone belongs to Miscellaneous.
Why it happens
Nitisinone inhibits CYP2C9-mediated diclofenac hydroxylation.
What to do
Use the lowest effective diclofenac dose and monitor for NSAID adverse effects, or choose an analgesic not metabolized by CYP2C9.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
- Ganciclovir + Nitisinone Moderate
Frequently asked questions
Can I take Diclofenac with Nitisinone?
MediHelp rates the interaction as moderate. Diclofenac and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitisinone inhibits CYP2C9 and may raise exposure to diclofenac, a CYP2C9 substrate. Higher diclofenac levels could increase gastrointestinal, renal and cardiovascular adverse effects.
How serious is the interaction between Diclofenac and Nitisinone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose and monitor for NSAID adverse effects, or choose an analgesic not metabolized by CYP2C9.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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