Drug interactions
Bosentan + Nitisinone
Severity: Moderate
Bosentan and Nitisinone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone weakly inhibits CYP2C9, one of the two main enzymes that clear bosentan. Bosentan exposure may rise modestly, increasing the likelihood of dose-related adverse effects such as liver enzyme elevation, edema and hypotension.
What this interaction means in plain words
Bosentan and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Nitisinone belongs to Miscellaneous.
Why it happens
Nitisinone inhibits CYP2C9, reducing the hepatic metabolism of bosentan.
What to do
Monitor liver aminotransferases and for signs of bosentan toxicity such as edema and low blood pressure. Reduce the bosentan dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bosentan and Nitisinone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
- Ganciclovir + Nitisinone Moderate
Frequently asked questions
Can I take Bosentan with Nitisinone?
MediHelp rates the interaction as moderate. Bosentan and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitisinone weakly inhibits CYP2C9, one of the two main enzymes that clear bosentan. Bosentan exposure may rise modestly, increasing the likelihood of dose-related adverse effects such as liver enzyme elevation, edema and hypotension.
How serious is the interaction between Bosentan and Nitisinone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver aminotransferases and for signs of bosentan toxicity such as edema and low blood pressure. Reduce the bosentan dose if adverse effects occur.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
