Drug interactions
Celecoxib + Nitisinone
Severity: Moderate
Celecoxib and Nitisinone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone can raise exposure to drugs cleared mainly by CYP2C9, including celecoxib. Higher celecoxib levels may increase gastrointestinal, renal and cardiovascular adverse effects.
What this interaction means in plain words
Celecoxib and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Nitisinone belongs to Miscellaneous.
Why it happens
Nitisinone inhibits CYP2C9, reducing celecoxib metabolism.
What to do
Reduce the celecoxib dose by about half when starting nitisinone, then titrate according to response and tolerability. Monitor for NSAID adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
- Ganciclovir + Nitisinone Moderate
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Nitisinone?
MediHelp rates the interaction as moderate. Celecoxib and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitisinone can raise exposure to drugs cleared mainly by CYP2C9, including celecoxib. Higher celecoxib levels may increase gastrointestinal, renal and cardiovascular adverse effects.
How serious is the interaction between Celecoxib and Nitisinone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the celecoxib dose by about half when starting nitisinone, then titrate according to response and tolerability. Monitor for NSAID adverse effects.
What other medicines interact with Nitisinone?
MediHelp also lists interactions of Nitisinone with, for example, Adefovir, Bosentan, Chlorpropamide. The full list is on the Nitisinone page.
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