Drug interactions
Chlorpropamide + Nitisinone
Severity: Moderate
Chlorpropamide and Nitisinone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone weakly inhibits CYP2C9, so it may increase chlorpropamide exposure. This could prolong or intensify glucose lowering and cause hypoglycemia, especially because chlorpropamide has a long half-life.
What this interaction means in plain words
Chlorpropamide and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Nitisinone belongs to Miscellaneous.
Why it happens
Nitisinone inhibits CYP2C9, reducing the metabolism of chlorpropamide.
What to do
Monitor blood glucose closely when starting or stopping nitisinone. Lower the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
- Ganciclovir + Nitisinone Moderate
Frequently asked questions
Can I take Chlorpropamide with Nitisinone?
MediHelp rates the interaction as moderate. Chlorpropamide and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitisinone weakly inhibits CYP2C9, so it may increase chlorpropamide exposure. This could prolong or intensify glucose lowering and cause hypoglycemia, especially because chlorpropamide has a long half-life.
How serious is the interaction between Chlorpropamide and Nitisinone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping nitisinone. Lower the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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