Drug interactions
Carvedilol + Propofol
Severity: Moderate
Carvedilol and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, and carvedilol adds alpha and beta blockade, so profound hypotension and bradycardia may occur during induction or sedation. Patients may also respond poorly to compensatory sympathetic activation.
What this interaction means in plain words
Carvedilol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Propofol belongs to Central Nervous System.
Why it happens
Additive hypotensive and negative chronotropic effects from vasodilation and adrenergic blockade.
What to do
Monitor blood pressure and heart rate continuously and titrate propofol slowly to effect. Have fluids and vasopressors or anticholinergics available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Propofol
Frequently asked questions
Can I take Carvedilol with Propofol?
MediHelp rates the interaction as moderate. Carvedilol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, and carvedilol adds alpha and beta blockade, so profound hypotension and bradycardia may occur during induction or sedation. Patients may also respond poorly to compensatory sympathetic activation.
How serious is the interaction between Carvedilol and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously and titrate propofol slowly to effect. Have fluids and vasopressors or anticholinergics available.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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