Drug interactions
Carvedilol + Talazoparib
Severity: Major
Carvedilol and Talazoparib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol inhibits P-glycoprotein, which can raise talazoparib exposure and increase hematologic toxicity such as anemia, neutropenia and thrombocytopenia. Talazoparib labeling identifies carvedilol among P-gp inhibitors that call for dose reduction.
What this interaction means in plain words
Carvedilol and Talazoparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carvedilol belongs to Cardiovascular; Talazoparib belongs to Oncology.
Why it happens
Carvedilol inhibits P-glycoprotein efflux of talazoparib, increasing its absorption and exposure.
What to do
Prefer an alternative beta-blocker if possible. If coadministration is necessary, reduce the talazoparib dose per labeling and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carvedilol
Other interactions of Talazoparib
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
- Dipyridamole + Talazoparib Moderate
Frequently asked questions
Can I take Carvedilol with Talazoparib?
MediHelp rates the interaction as major. Carvedilol and Talazoparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carvedilol inhibits P-glycoprotein, which can raise talazoparib exposure and increase hematologic toxicity such as anemia, neutropenia and thrombocytopenia. Talazoparib labeling identifies carvedilol among P-gp inhibitors that call for dose reduction.
How serious is the interaction between Carvedilol and Talazoparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative beta-blocker if possible. If coadministration is necessary, reduce the talazoparib dose per labeling and monitor blood counts closely.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Albuterol, Amifostine, Amiodarone. The full list is on the Carvedilol page.
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