Drug interactions
Itraconazole + Talazoparib
Severity: Major
Itraconazole and Talazoparib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole inhibits P-glycoprotein and can raise talazoparib exposure. This increases the risk of hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Itraconazole and Talazoparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Talazoparib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux of talazoparib by itraconazole, increasing absorption and reducing elimination.
What to do
Avoid if possible. If it cannot be avoided, reduce the talazoparib dose per labeling and monitor blood counts, then restore the original dose after the inhibitor has been stopped for several half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
- Dipyridamole + Talazoparib Moderate
Frequently asked questions
Can I take Itraconazole with Talazoparib?
MediHelp rates the interaction as major. Itraconazole and Talazoparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole inhibits P-glycoprotein and can raise talazoparib exposure. This increases the risk of hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Itraconazole and Talazoparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If it cannot be avoided, reduce the talazoparib dose per labeling and monitor blood counts, then restore the original dose after the inhibitor has been stopped for several half-lives.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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