Drug interactions
Azithromycin + Talazoparib
Severity: Moderate
Azithromycin and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talazoparib is a P-glycoprotein substrate, so P-glycoprotein inhibitors may raise its exposure and the risk of myelosuppression. Azithromycin is only a weak inhibitor, so the effect is probably modest.
What this interaction means in plain words
Azithromycin and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Talazoparib belongs to Oncology.
Why it happens
Possible P-glycoprotein inhibition by azithromycin increasing talazoparib absorption.
What to do
Monitor blood counts closely and consider reducing the talazoparib dose if toxicity develops. Use an alternative antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
- Dipyridamole + Talazoparib Moderate
Frequently asked questions
Can I take Azithromycin with Talazoparib?
MediHelp rates the interaction as moderate. Azithromycin and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talazoparib is a P-glycoprotein substrate, so P-glycoprotein inhibitors may raise its exposure and the risk of myelosuppression. Azithromycin is only a weak inhibitor, so the effect is probably modest.
How serious is the interaction between Azithromycin and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and consider reducing the talazoparib dose if toxicity develops. Use an alternative antibiotic if feasible.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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