Drug interactions
Dipyridamole + Talazoparib
Severity: Moderate
Dipyridamole and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole inhibits BCRP and may increase talazoparib exposure, raising the risk of anemia and thrombocytopenia. The interaction is mechanism-based and not well characterized.
What this interaction means in plain words
Dipyridamole and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dipyridamole belongs to Cardiovascular; Talazoparib belongs to Oncology.
Why it happens
Dipyridamole inhibits BCRP-mediated efflux of talazoparib, potentially increasing its exposure.
What to do
Monitor blood counts and reduce the talazoparib dose if hematologic toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Dipyridamole with Talazoparib?
MediHelp rates the interaction as moderate. Dipyridamole and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipyridamole inhibits BCRP and may increase talazoparib exposure, raising the risk of anemia and thrombocytopenia. The interaction is mechanism-based and not well characterized.
How serious is the interaction between Dipyridamole and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and reduce the talazoparib dose if hematologic toxicity occurs.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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