Drug interactions
Cyclosporin + Talazoparib
Severity: Moderate
Cyclosporin and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits BCRP and P-gp and may increase talazoparib exposure. This can worsen myelosuppression such as anaemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Cyclosporin and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Talazoparib belongs to Oncology.
Why it happens
Inhibition of BCRP/P-gp efflux of talazoparib.
What to do
Prefer an alternative to cyclosporine if possible. If coadministration is needed, monitor blood counts regularly and reduce the talazoparib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Dipyridamole + Talazoparib Moderate
Frequently asked questions
Can I take Cyclosporin with Talazoparib?
MediHelp rates the interaction as moderate. Cyclosporin and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits BCRP and P-gp and may increase talazoparib exposure. This can worsen myelosuppression such as anaemia, neutropenia and thrombocytopenia.
How serious is the interaction between Cyclosporin and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to cyclosporine if possible. If coadministration is needed, monitor blood counts regularly and reduce the talazoparib dose if toxicity occurs.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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