Drug interactions
Clarithromycin + Talazoparib
Severity: Moderate
Clarithromycin and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase talazoparib exposure, raising the risk of myelosuppression including anemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Clarithromycin and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Talazoparib belongs to Oncology.
Why it happens
Clarithromycin inhibits P-glycoprotein-mediated efflux of talazoparib.
What to do
Prefer an alternative antibiotic. If unavoidable, reduce the talazoparib dose per labeling and return to the prior dose after 3 to 5 half-lives of clarithromycin; monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
- Dipyridamole + Talazoparib Moderate
Frequently asked questions
Can I take Clarithromycin with Talazoparib?
MediHelp rates the interaction as moderate. Clarithromycin and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may increase talazoparib exposure, raising the risk of myelosuppression including anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Clarithromycin and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic. If unavoidable, reduce the talazoparib dose per labeling and return to the prior dose after 3 to 5 half-lives of clarithromycin; monitor blood counts.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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