Drug interactions
Carvedilol + Ticlopidine
Severity: Minor
Carvedilol and Ticlopidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits several CYP enzymes, including CYP2C19 and CYP2D6, and may raise carvedilol concentrations. This could increase bradycardia and hypotension, though the clinical significance is uncertain.
What this interaction means in plain words
Carvedilol and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibition of hepatic CYP enzymes (notably CYP2D6 and CYP2C19) may reduce carvedilol metabolism.
What to do
Monitor heart rate and blood pressure when starting ticlopidine and reduce the carvedilol dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Ticlopidine
Frequently asked questions
Can I take Carvedilol with Ticlopidine?
MediHelp rates the interaction as minor. Carvedilol and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticlopidine inhibits several CYP enzymes, including CYP2C19 and CYP2D6, and may raise carvedilol concentrations. This could increase bradycardia and hypotension, though the clinical significance is uncertain.
How serious is the interaction between Carvedilol and Ticlopidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting ticlopidine and reduce the carvedilol dose if bradycardia or hypotension occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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