Drug interactions
Carvedilol + Tucatinib
Severity: Moderate
Carvedilol and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein, and carvedilol is a P-gp substrate, so carvedilol exposure may increase. This may lead to bradycardia or hypotension.
What this interaction means in plain words
Carvedilol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition increases carvedilol absorption and reduces efflux.
What to do
Monitor heart rate and blood pressure and consider reducing the carvedilol dose if symptoms of excess beta-blockade appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carvedilol and Tucatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carvedilol
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Carvedilol with Tucatinib?
MediHelp rates the interaction as moderate. Carvedilol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits P-glycoprotein, and carvedilol is a P-gp substrate, so carvedilol exposure may increase. This may lead to bradycardia or hypotension.
How serious is the interaction between Carvedilol and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and consider reducing the carvedilol dose if symptoms of excess beta-blockade appear.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
