Drug interactions
Ergotamine + Tucatinib
Severity: Contraindicated
Ergotamine and Tucatinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and can markedly raise concentrations of sensitive substrates such as ergotamine. Elevated ergotamine exposure risks ergotism, with severe peripheral and cerebral vasospasm and ischemia.
What this interaction means in plain words
Ergotamine and Tucatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ergotamine belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing the first-pass and systemic clearance of ergotamine.
What to do
Avoid concurrent use and choose a non-ergot migraine therapy such as a triptan or CGRP-targeted agent. If the combination cannot be avoided, monitor closely for limb ischemia, paresthesias and severe headache.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
- Apalutamide + Tucatinib Major
Frequently asked questions
Can I take Ergotamine with Tucatinib?
MediHelp rates the interaction as contraindicated. Ergotamine and Tucatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tucatinib inhibits CYP3A4 and can markedly raise concentrations of sensitive substrates such as ergotamine. Elevated ergotamine exposure risks ergotism, with severe peripheral and cerebral vasospasm and ischemia.
How serious is the interaction between Ergotamine and Tucatinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-ergot migraine therapy such as a triptan or CGRP-targeted agent. If the combination cannot be avoided, monitor closely for limb ischemia, paresthesias and severe headache.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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