Drug interactions
Cisapride + Tucatinib
Severity: Contraindicated
Cisapride and Tucatinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and can raise cisapride concentrations, increasing the risk of QT prolongation and life-threatening arrhythmias such as torsades de pointes. Cisapride is contraindicated with strong or moderate CYP3A4 inhibitors.
What this interaction means in plain words
Cisapride and Tucatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cisapride belongs to Gastrointestinal Tract; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated cisapride metabolism raises plasma levels and QT risk.
What to do
Do not coadminister; use an alternative prokinetic that is not a CYP3A4 substrate with QT risk.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cisapride and Tucatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Tucatinib
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
- Apalutamide + Tucatinib Major
Frequently asked questions
Can I take Cisapride with Tucatinib?
MediHelp rates the interaction as contraindicated. Cisapride and Tucatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tucatinib inhibits CYP3A4 and can raise cisapride concentrations, increasing the risk of QT prolongation and life-threatening arrhythmias such as torsades de pointes. Cisapride is contraindicated with strong or moderate CYP3A4 inhibitors.
How serious is the interaction between Cisapride and Tucatinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative prokinetic that is not a CYP3A4 substrate with QT risk.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
