Drug interactions
Ranolazine + Tucatinib
Severity: Contraindicated
Ranolazine and Tucatinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and can substantially raise ranolazine concentrations. This increases QT prolongation and dose-related adverse effects.
What this interaction means in plain words
Ranolazine and Tucatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ranolazine belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing ranolazine metabolism.
What to do
Avoid the combination, since ranolazine is contraindicated with strong CYP3A inhibitors. Use an alternative antianginal during tucatinib therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
- Apalutamide + Tucatinib Major
Frequently asked questions
Can I take Ranolazine with Tucatinib?
MediHelp rates the interaction as contraindicated. Ranolazine and Tucatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tucatinib is a strong CYP3A inhibitor and can substantially raise ranolazine concentrations. This increases QT prolongation and dose-related adverse effects.
How serious is the interaction between Ranolazine and Tucatinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, since ranolazine is contraindicated with strong CYP3A inhibitors. Use an alternative antianginal during tucatinib therapy.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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