Drug interactions
Eletriptan + Tucatinib
Severity: Contraindicated
Eletriptan and Tucatinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and may markedly increase eletriptan exposure, which depends on CYP3A4 metabolism. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors due to excessive exposure and vasoconstrictive effects.
What this interaction means in plain words
Eletriptan and Tucatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eletriptan belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by tucatinib reduces eletriptan metabolism and raises systemic exposure.
What to do
Avoid eletriptan during tucatinib therapy. Use a triptan not metabolized by CYP3A4, such as sumatriptan or naratriptan.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
- Apalutamide + Tucatinib Major
Frequently asked questions
Can I take Eletriptan with Tucatinib?
MediHelp rates the interaction as contraindicated. Eletriptan and Tucatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tucatinib is a strong CYP3A inhibitor and may markedly increase eletriptan exposure, which depends on CYP3A4 metabolism. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors due to excessive exposure and vasoconstrictive effects.
How serious is the interaction between Eletriptan and Tucatinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan during tucatinib therapy. Use a triptan not metabolized by CYP3A4, such as sumatriptan or naratriptan.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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