Drug interactions
Flibanserin + Tucatinib
Severity: Contraindicated
Flibanserin and Tucatinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor and may raise flibanserin exposure. This increases risk of hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Tucatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Flibanserin belongs to Genitourinary; Tucatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by tucatinib reduces flibanserin clearance.
What to do
Avoid concurrent use; flibanserin is contraindicated with moderate or strong CYP3A4 inhibitors.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
- Apalutamide + Tucatinib Major
Frequently asked questions
Can I take Flibanserin with Tucatinib?
MediHelp rates the interaction as contraindicated. Flibanserin and Tucatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tucatinib is a moderate CYP3A inhibitor and may raise flibanserin exposure. This increases risk of hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Tucatinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; flibanserin is contraindicated with moderate or strong CYP3A4 inhibitors.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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