Drug interactions
Caspofungin + Sofosbuvir-velpatasvir
Severity: Minor
Caspofungin and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caspofungin is taken up into the liver by OATP1B1, which velpatasvir inhibits. Caspofungin concentrations may increase somewhat, but the clinical impact is likely small.
What this interaction means in plain words
Caspofungin and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caspofungin belongs to Anti Fungals; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir inhibits OATP-mediated hepatic uptake of caspofungin.
What to do
No dose change is needed; monitor liver enzymes during combined therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Frequently asked questions
Can I take Caspofungin with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Caspofungin and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caspofungin is taken up into the liver by OATP1B1, which velpatasvir inhibits. Caspofungin concentrations may increase somewhat, but the clinical impact is likely small.
How serious is the interaction between Caspofungin and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor liver enzymes during combined therapy.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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