Drug interactions
Cefaclor + Furosemide
Severity: Minor
Cefaclor and Furosemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some cephalosporins have been associated with additive kidney injury when given with potent loop diuretics, especially in volume-depleted or older patients. Cefaclor has little nephrotoxicity of its own, so the risk is modest.
What this interaction means in plain words
Cefaclor and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefaclor belongs to Anti Bacterial; Furosemide belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion and reduced renal perfusion may add to cephalosporin renal effects and slow its elimination.
What to do
Maintain hydration and monitor serum creatinine in patients with renal impairment or volume depletion. Adjust cefaclor dose to renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefaclor
- Bcg vaccine live + Cefaclor Moderate
- Cefaclor + Cholera vaccine Moderate
- Cefaclor + Kanamycin Moderate
- Cefaclor + Microbiota Moderate
- Cefaclor + Plazomicin Moderate
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Cefaclor with Furosemide?
MediHelp rates the interaction as minor. Cefaclor and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some cephalosporins have been associated with additive kidney injury when given with potent loop diuretics, especially in volume-depleted or older patients. Cefaclor has little nephrotoxicity of its own, so the risk is modest.
How serious is the interaction between Cefaclor and Furosemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor serum creatinine in patients with renal impairment or volume depletion. Adjust cefaclor dose to renal function.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.
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