Drug interactions
Cefadroxil + Digoxin
Severity: Minor
Cefadroxil and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral antibiotics can reduce gut bacteria that inactivate digoxin, which may increase digoxin absorption and serum levels in a minority of patients. This is well described mainly with macrolides and tetracyclines, and is less established for cefadroxil.
What this interaction means in plain words
Cefadroxil and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Digoxin belongs to Cardiovascular.
Why it happens
Suppression of Eubacterium lentum in the gut reduces digoxin inactivation, increasing bioavailability.
What to do
Monitor for digoxin toxicity symptoms and check digoxin levels if signs appear during antibiotic therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Cefadroxil with Digoxin?
MediHelp rates the interaction as minor. Cefadroxil and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral antibiotics can reduce gut bacteria that inactivate digoxin, which may increase digoxin absorption and serum levels in a minority of patients. This is well described mainly with macrolides and tetracyclines, and is less established for cefadroxil.
How serious is the interaction between Cefadroxil and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for digoxin toxicity symptoms and check digoxin levels if signs appear during antibiotic therapy.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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