Drug interactions
Cefadroxil + Estradiol
Severity: Minor
Cefadroxil and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics were theorized to lower oral estrogen levels by disrupting enterohepatic recirculation. Pharmacokinetic and epidemiological data show no consistent effect for non-rifamycin antibiotics, so any risk is very low.
What this interaction means in plain words
Cefadroxil and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Estradiol belongs to Endocrine.
Why it happens
Theoretical reduction of gut bacterial deconjugation of estrogen conjugates, decreasing enterohepatic recirculation.
What to do
No action is generally required. Advise patients to report breakthrough bleeding or loss of symptom control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Cefadroxil with Estradiol?
MediHelp rates the interaction as minor. Cefadroxil and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics were theorized to lower oral estrogen levels by disrupting enterohepatic recirculation. Pharmacokinetic and epidemiological data show no consistent effect for non-rifamycin antibiotics, so any risk is very low.
How serious is the interaction between Cefadroxil and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required. Advise patients to report breakthrough bleeding or loss of symptom control.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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