Drug interactions
Cefazolin + Furosemide
Severity: Minor
Cefazolin and Furosemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some cephalosporins have been associated with additive kidney injury when given with potent loop diuretics, especially in volume-depleted or older patients. Cefazolin has relatively low nephrotoxic potential, so the risk is modest. Reduced renal function also slows cefazolin clearance.
What this interaction means in plain words
Cefazolin and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefazolin belongs to Anti Bacterial; Furosemide belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion and reduced renal perfusion may add to cephalosporin renal effects and slow its elimination.
What to do
Maintain hydration and monitor serum creatinine in patients with renal impairment or volume depletion. Adjust cefazolin dose to renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefazolin
- Amikacin + Cefazolin Moderate
- Bcg vaccine live + Cefazolin Moderate
- Cefazolin + Cholera vaccine Moderate
- Cefazolin + Dexamethasone-tobramycin Moderate
- Cefazolin + Gentamicin Moderate
- Cefazolin + Kanamycin Moderate
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Cefazolin with Furosemide?
MediHelp rates the interaction as minor. Cefazolin and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some cephalosporins have been associated with additive kidney injury when given with potent loop diuretics, especially in volume-depleted or older patients. Cefazolin has relatively low nephrotoxic potential, so the risk is modest. Reduced renal function also slows cefazolin clearance.
How serious is the interaction between Cefazolin and Furosemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor serum creatinine in patients with renal impairment or volume depletion. Adjust cefazolin dose to renal function.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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