Drug interactions
Cefditoren + Ibuprofen / famotidine
Severity: Moderate
Cefditoren and Ibuprofen / famotidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine raises gastric pH, which reduces the absorption of cefditoren pivoxil and lowers its systemic exposure. This may compromise antibacterial efficacy.
What this interaction means in plain words
Cefditoren and Ibuprofen / famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Higher gastric pH reduces dissolution and absorption of cefditoren pivoxil.
What to do
Avoid concurrent use where possible; if acid suppression is required, consider an alternative antibiotic and monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefditoren
- Aluminum hydroxide + Cefditoren Moderate
- Calcium carbonate + Cefditoren Moderate
- Calcium + Cefditoren Moderate
- Cefditoren + Cholera vaccine Moderate
- Cefditoren + Cimetidine Moderate
- Cefditoren + Dexlansoprazole Moderate
Frequently asked questions
Can I take Cefditoren with Ibuprofen / famotidine?
MediHelp rates the interaction as moderate. Cefditoren and Ibuprofen / famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine raises gastric pH, which reduces the absorption of cefditoren pivoxil and lowers its systemic exposure. This may compromise antibacterial efficacy.
How serious is the interaction between Cefditoren and Ibuprofen / famotidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if acid suppression is required, consider an alternative antibiotic and monitor clinical response.
What other medicines interact with Cefditoren?
MediHelp also lists interactions of Cefditoren with, for example, Aluminum hydroxide, Calcium carbonate, Calcium. The full list is on the Cefditoren page.
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