Drug interactions
Cefditoren + Cimetidine
Severity: Moderate
Cefditoren and Cimetidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefditoren absorption falls when gastric acidity is suppressed by H2 blockers. Reduced exposure may compromise treatment of infection.
What this interaction means in plain words
Cefditoren and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefditoren belongs to Anti Bacterial; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces cefditoren pivoxil dissolution and absorption.
What to do
Avoid concomitant use where possible and consider another antibiotic. Otherwise monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Cefditoren
- Aluminum hydroxide + Cefditoren Moderate
- Calcium carbonate + Cefditoren Moderate
- Calcium + Cefditoren Moderate
- Cefditoren + Cholera vaccine Moderate
- Cefditoren + Dexlansoprazole Moderate
- Cefditoren + Famotidine Moderate
Frequently asked questions
Can I take Cefditoren with Cimetidine?
MediHelp rates the interaction as moderate. Cefditoren and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefditoren absorption falls when gastric acidity is suppressed by H2 blockers. Reduced exposure may compromise treatment of infection.
How serious is the interaction between Cefditoren and Cimetidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible and consider another antibiotic. Otherwise monitor clinical response.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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