Drug interactions
Cefditoren + Kanamycin
Severity: Moderate
Cefditoren and Kanamycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides are nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additive kidney injury when combined with them. The effect is mainly reported with parenteral aminoglycosides in patients with other risk factors.
What this interaction means in plain words
Cefditoren and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive nephrotoxicity; the aminoglycoside itself causes proximal tubular and cochlear toxicity.
What to do
Monitor serum creatinine and aminoglycoside levels, keep the patient well hydrated, and adjust doses for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefditoren
- Aluminum hydroxide + Cefditoren Moderate
- Calcium carbonate + Cefditoren Moderate
- Calcium + Cefditoren Moderate
- Cefditoren + Cholera vaccine Moderate
- Cefditoren + Cimetidine Moderate
- Cefditoren + Dexlansoprazole Moderate
Frequently asked questions
Can I take Cefditoren with Kanamycin?
MediHelp rates the interaction as moderate. Cefditoren and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides are nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additive kidney injury when combined with them. The effect is mainly reported with parenteral aminoglycosides in patients with other risk factors.
How serious is the interaction between Cefditoren and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and aminoglycoside levels, keep the patient well hydrated, and adjust doses for renal function.
What other medicines interact with Cefditoren?
MediHelp also lists interactions of Cefditoren with, for example, Aluminum hydroxide, Calcium carbonate, Calcium. The full list is on the Cefditoren page.
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