Drug interactions
Cefepime + Furosemide
Severity: Minor
Cefepime and Furosemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics can cause volume depletion and reduced renal perfusion, which may impair clearance of cefepime. Accumulated cefepime increases the risk of neurotoxicity such as encephalopathy and seizures, and reports of direct additive nephrotoxicity are inconsistent.
What this interaction means in plain words
Cefepime and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefepime belongs to Anti Bacterial; Furosemide belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion may reduce renal function and thus cefepime clearance; direct nephrotoxic synergy is not well established.
What to do
Monitor renal function and hydration status, and adjust the cefepime dose to creatinine clearance. Watch for altered mental status or myoclonus.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cefepime and Furosemide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cefepime
- Amikacin + Cefepime Moderate
- Cefepime + Cholera vaccine Moderate
- Cefepime + Dexamethasone-tobramycin Moderate
- Cefepime + Gentamicin Moderate
- Cefepime + Kanamycin Moderate
- Cefepime + Microbiota Moderate
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Cefepime with Furosemide?
MediHelp rates the interaction as minor. Cefepime and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Loop diuretics can cause volume depletion and reduced renal perfusion, which may impair clearance of cefepime. Accumulated cefepime increases the risk of neurotoxicity such as encephalopathy and seizures, and reports of direct additive nephrotoxicity are inconsistent.
How serious is the interaction between Cefepime and Furosemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hydration status, and adjust the cefepime dose to creatinine clearance. Watch for altered mental status or myoclonus.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
