Drug interactions
Cefotaxime + Plazomicin
Severity: Minor
Cefotaxime and Plazomicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Plazomicin is nephrotoxic and ototoxic, and other agents that may affect renal function could add to kidney injury risk. Cefotaxime is only weakly nephrotoxic, so the added risk is modest, but renal impairment would raise plazomicin exposure.
What this interaction means in plain words
Cefotaxime and Plazomicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefotaxime belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity, with the aminoglycoside accounting for most of the risk.
What to do
Monitor serum creatinine and plazomicin trough concentrations per labeling. Adjust the plazomicin dose if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefotaxime
- Cefotaxime + Typhoid vaccine live Major
- Amikacin + Cefotaxime Moderate
- Cefotaxime + Cholera vaccine Moderate
- Cefotaxime + Dexamethasone-tobramycin Moderate
- Cefotaxime + Gentamicin Moderate
- Cefotaxime + Kanamycin Moderate
Other interactions of Plazomicin
- Cefaclor + Plazomicin Moderate
- Cefadroxil + Plazomicin Moderate
- Cefalexin + Plazomicin Moderate
- Cefazolin + Plazomicin Moderate
- Cefditoren + Plazomicin Moderate
- Cefepime + Plazomicin Moderate
Frequently asked questions
Can I take Cefotaxime with Plazomicin?
MediHelp rates the interaction as minor. Cefotaxime and Plazomicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Plazomicin is nephrotoxic and ototoxic, and other agents that may affect renal function could add to kidney injury risk. Cefotaxime is only weakly nephrotoxic, so the added risk is modest, but renal impairment would raise plazomicin exposure.
How serious is the interaction between Cefotaxime and Plazomicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin trough concentrations per labeling. Adjust the plazomicin dose if renal function declines.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Amikacin, Cholera vaccine. The full list is on the Cefotaxime page.
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