Drug interactions
Cefotetan + Chloramphenicol
Severity: Minor
Cefotetan and Chloramphenicol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may reduce the bactericidal effect of cefotetan, as shown mainly in laboratory data. Clinical impact is uncertain but may matter in severe infections.
What this interaction means in plain words
Cefotetan and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefotetan belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism: bacteriostatic suppression of bacterial growth reduces the activity of a growth-dependent bactericidal beta-lactam.
What to do
Avoid the combination in serious infections when possible; otherwise monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloramphenicol
Other interactions of Cefotetan
- Cefotetan + Dronabinol Contraindicated
- Cefotetan + Warfarin Major
- Amikacin + Cefotetan Moderate
- Argatroban + Cefotetan Moderate
- Cefotetan + Dalteparin Moderate
- Cefotetan + Enoxaparin Moderate
Frequently asked questions
Can I take Cefotetan with Chloramphenicol?
MediHelp rates the interaction as minor. Cefotetan and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol may reduce the bactericidal effect of cefotetan, as shown mainly in laboratory data. Clinical impact is uncertain but may matter in severe infections.
How serious is the interaction between Cefotetan and Chloramphenicol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in serious infections when possible; otherwise monitor clinical response.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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