Drug interactions
Cefotetan + Probenecid
Severity: Minor
Cefotetan and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid slows the renal tubular secretion of cefotetan, raising and prolonging its serum concentrations. The effect is usually modest and not harmful.
What this interaction means in plain words
Cefotetan and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefotetan belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid competes for renal tubular secretion of cefotetan.
What to do
No routine adjustment is needed; consider dose reduction in renal impairment and monitor for adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Cefotetan
- Cefotetan + Dronabinol Contraindicated
- Cefotetan + Warfarin Major
- Amikacin + Cefotetan Moderate
- Argatroban + Cefotetan Moderate
- Cefotetan + Dalteparin Moderate
- Cefotetan + Enoxaparin Moderate
Frequently asked questions
Can I take Cefotetan with Probenecid?
MediHelp rates the interaction as minor. Cefotetan and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid slows the renal tubular secretion of cefotetan, raising and prolonging its serum concentrations. The effect is usually modest and not harmful.
How serious is the interaction between Cefotetan and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; consider dose reduction in renal impairment and monitor for adverse effects.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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