Drug interactions
Cefpirome + Streptomycin
Severity: Moderate
Cefpirome and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins given with aminoglycosides have been associated with increased kidney injury in some reports, though the effect is inconsistent and is modest for newer agents. Combination is common in practice.
What this interaction means in plain words
Cefpirome and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpirome belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity; mechanism is not well established.
What to do
Monitor serum creatinine and urine output during combined therapy and adjust the streptomycin dose according to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion-naltrexone + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Gentamicin Moderate
- Acetylsalicylic acid + Cefpirome Minor
Frequently asked questions
Can I take Cefpirome with Streptomycin?
MediHelp rates the interaction as moderate. Cefpirome and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins given with aminoglycosides have been associated with increased kidney injury in some reports, though the effect is inconsistent and is modest for newer agents. Combination is common in practice.
How serious is the interaction between Cefpirome and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output during combined therapy and adjust the streptomycin dose according to renal function.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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