Drug interactions
Bupropion-naltrexone + Cefpirome
Severity: Moderate
Bupropion-naltrexone and Cefpirome: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins such as cefpirome can lower the seizure threshold, especially in renal impairment. Combined with bupropion, which is itself dose-dependently epileptogenic, seizure risk may rise.
What this interaction means in plain words
Bupropion-naltrexone and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Cefpirome belongs to Anti Bacterial.
Why it happens
Additive lowering of seizure threshold through pharmacodynamic effects.
What to do
Adjust cefpirome dose to renal function and avoid exceeding the lowest effective bupropion dose. Monitor for neurological symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Gentamicin Moderate
- Cefpirome + Streptomycin Moderate
- Acetylsalicylic acid + Cefpirome Minor
Frequently asked questions
Can I take Bupropion-naltrexone with Cefpirome?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins such as cefpirome can lower the seizure threshold, especially in renal impairment. Combined with bupropion, which is itself dose-dependently epileptogenic, seizure risk may rise.
How serious is the interaction between Bupropion-naltrexone and Cefpirome?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust cefpirome dose to renal function and avoid exceeding the lowest effective bupropion dose. Monitor for neurological symptoms.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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