Drug interactions
Cefpodoxime + Famotidine
Severity: Moderate
Cefpodoxime and Famotidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefpodoxime proxetil needs gastric acid for dissolution and absorption, so H2 blockers lower its systemic exposure. This can reduce antibacterial efficacy.
What this interaction means in plain words
Cefpodoxime and Famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpodoxime belongs to Anti Bacterial; Famotidine belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces dissolution and absorption of cefpodoxime proxetil.
What to do
Avoid the combination if possible, or choose an antibiotic not dependent on gastric acidity. Monitor the clinical response to treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Frequently asked questions
Can I take Cefpodoxime with Famotidine?
MediHelp rates the interaction as moderate. Cefpodoxime and Famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefpodoxime proxetil needs gastric acid for dissolution and absorption, so H2 blockers lower its systemic exposure. This can reduce antibacterial efficacy.
How serious is the interaction between Cefpodoxime and Famotidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or choose an antibiotic not dependent on gastric acidity. Monitor the clinical response to treatment.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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