Drug interactions
Cefpodoxime + Voclosporin
Severity: Minor
Cefpodoxime and Voclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is dose-dependently nephrotoxic, while cefpodoxime has little intrinsic nephrotoxicity. Additive kidney injury is possible only in susceptible patients and is poorly documented.
What this interaction means in plain words
Cefpodoxime and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefpodoxime belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Possible additive renal injury; no established pharmacokinetic interaction.
What to do
Monitor serum creatinine and eGFR as required with voclosporin, and reduce the cefpodoxime dosing interval if creatinine clearance is below 30 mL/min.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Cefpodoxime with Voclosporin?
MediHelp rates the interaction as minor. Cefpodoxime and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voclosporin is dose-dependently nephrotoxic, while cefpodoxime has little intrinsic nephrotoxicity. Additive kidney injury is possible only in susceptible patients and is poorly documented.
How serious is the interaction between Cefpodoxime and Voclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR as required with voclosporin, and reduce the cefpodoxime dosing interval if creatinine clearance is below 30 mL/min.
What other medicines interact with Cefpodoxime?
MediHelp also lists interactions of Cefpodoxime with, for example, Aluminum hydroxide, Amikacin, Calcium carbonate. The full list is on the Cefpodoxime page.
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