Drug interactions
Cefpodoxime + Warfarin
Severity: Moderate
Cefpodoxime and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins have been associated with increased INR and bleeding in patients taking warfarin, mainly in ill or elderly patients. The effect is inconsistent and may partly reflect the underlying infection and reduced intake.
What this interaction means in plain words
Cefpodoxime and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpodoxime belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Why it happens
Possible reduction of vitamin K-producing gut flora and variable effects on vitamin K-dependent clotting; the mechanism is not firmly established.
What to do
Check the INR within a few days of starting cefpodoxime and again after the course ends. Adjust the warfarin dose based on INR and watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cefpodoxime and Warfarin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Cefpodoxime with Warfarin?
MediHelp rates the interaction as moderate. Cefpodoxime and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins have been associated with increased INR and bleeding in patients taking warfarin, mainly in ill or elderly patients. The effect is inconsistent and may partly reflect the underlying infection and reduced intake.
How serious is the interaction between Cefpodoxime and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the INR within a few days of starting cefpodoxime and again after the course ends. Adjust the warfarin dose based on INR and watch for bleeding.
What other medicines interact with Cefpodoxime?
MediHelp also lists interactions of Cefpodoxime with, for example, Aluminum hydroxide, Amikacin, Calcium carbonate. The full list is on the Cefpodoxime page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
