Drug interactions
Ceftaroline fosamil + Tobramycin
Severity: Moderate
Ceftaroline fosamil and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tobramycin is nephrotoxic and ototoxic, and concurrent cephalosporin use has been associated with additional renal injury in some reports. Ceftaroline has little direct nephrotoxicity, so the added risk is modest but matters in renal impairment.
What this interaction means in plain words
Ceftaroline fosamil and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceftaroline fosamil belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
Why it happens
Additive renal tubular stress, with reduced renal function increasing aminoglycoside accumulation.
What to do
Monitor serum creatinine and tobramycin trough levels and adjust doses to renal function. Limit combined duration and watch for hearing or balance changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceftaroline fosamil
- Amikacin + Ceftaroline fosamil Moderate
- Ceftaroline fosamil + Cholera vaccine Moderate
- Ceftaroline fosamil + Gentamicin Moderate
- Ceftaroline fosamil + Kanamycin Moderate
- Ceftaroline fosamil + Microbiota Moderate
- Ceftaroline fosamil + Plazomicin Moderate
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Ceftaroline fosamil with Tobramycin?
MediHelp rates the interaction as moderate. Ceftaroline fosamil and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tobramycin is nephrotoxic and ototoxic, and concurrent cephalosporin use has been associated with additional renal injury in some reports. Ceftaroline has little direct nephrotoxicity, so the added risk is modest but matters in renal impairment.
How serious is the interaction between Ceftaroline fosamil and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough levels and adjust doses to renal function. Limit combined duration and watch for hearing or balance changes.
What other medicines interact with Ceftaroline fosamil?
MediHelp also lists interactions of Ceftaroline fosamil with, for example, Amikacin, Cholera vaccine, Gentamicin. The full list is on the Ceftaroline fosamil page.
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