Drug interactions
Ceftazidime + Probenecid
Severity: Minor
Ceftazidime and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftazidime is cleared mainly by glomerular filtration. Probenecid has little to no meaningful effect on its elimination, so a clinically relevant interaction is not expected.
What this interaction means in plain words
Ceftazidime and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceftazidime belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Tubular secretion contributes little to ceftazidime clearance, so any transporter competition has a minimal effect.
What to do
No action is needed beyond awareness. In severe renal impairment, monitor for neurotoxicity as with any ceftazidime therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ceftazidime and Probenecid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Ceftazidime
- Amikacin + Ceftazidime Moderate
- Ceftazidime + Cholera vaccine Moderate
- Ceftazidime + Dexamethasone-tobramycin Moderate
- Ceftazidime + Gentamicin Moderate
- Ceftazidime + Kanamycin Moderate
- Ceftazidime + Microbiota Moderate
Frequently asked questions
Can I take Ceftazidime with Probenecid?
MediHelp rates the interaction as minor. Ceftazidime and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftazidime is cleared mainly by glomerular filtration. Probenecid has little to no meaningful effect on its elimination, so a clinically relevant interaction is not expected.
How serious is the interaction between Ceftazidime and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond awareness. In severe renal impairment, monitor for neurotoxicity as with any ceftazidime therapy.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
